What can systems pharmacology contribute to drug development? Disease modelling as a predictive toolThe paper "The Apoe-/- Mouse PhysioLab® Platform: A Validated Physiologically-based Mathematical Model of Atherosclerotic Plaque Progression in the Apoe-/- Mouse" by Jason Chan and colleagues  published in BioDiscovery 2012; 3: 2 is significant for several reasons. The pharmaceutical and biotechnology industries have become quite proficient at rational drug design, but rational drug development has not progressed as quickly (and development costs represent at least 70% of the billion dollar cost of taking a new chemical entity from conception to market)... Read more
To see an interphase chromosome or: How a disease can be associated with specific nuclear genome organizationA study in this issue of BioDiscovery, Does positioning of chromosomes 8 and 21 in interphase drive t(8;21) in acute myelogenous leukemia?, shows the way of how to identify interphase chromosome architecture at molecular resolutions and demonstrates the involvement of specific nuclear genome organization in generating a cancer- causing chromosomal aberration (translocation between chromosomes 8 and 21 in acute myelogenous leukemia). Authors’ findings suggest interphase molecular cytogenetic techniques (i.e. interphase chromosome-specific multicolor banding or ICS-MCB) to be required to perform studies regarding nuclear genome organization at chromosomal level and its role in disease pathogenesis... Read more
BioDiscovery is an international, open access, online, peer-reviewed journal for the communication of primary research from any scientific discipline in the field of life sciences and medicine. Main characteristics of the journal are:
- High quality of published papers, controlled by distinguished world-class researchers. Closed and open peer review systems.
- Rapid publication. Articles are published online immediately after manuscript acceptance.
- No limit in manuscript length. Large reviews and monograph-type papers will be published as special journal issues and assigned ISBN numbers.
- Open access - all published papers can be freely copied, downloaded, printed and distributed at no charge for the reader. Authors retain copyright.
- Worldwide dissemination of the journal content to indexing databases and archiving in open-repositories.
- Possibility for post-publication comments on articles.
- Very competitive publication charges
- Annual ‘Most Cited Paper of the Year Award’ comprising of £1000 and a certificate given at the Annual BioDundee Conference, where the corresponding author of the winning paper will be sponsored to participate.