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To see an interphase chromosome or: How a disease can be associated with specific nuclear genome organization

To see an interphase chromosome or: How a disease can be associated with specific nuclear genome organization

Posted on October 10, 2019October 10, 2019 by Rose Ladwig

Background

During interphase, chromosomes occupy non-random positions within the nuclear space. Interphase chromosome arrangement is considered to play significant role in development and disease mediated by regulation of genome expression and stability maintenance [1, 2]. However, some …

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Commentary What can systems pharmacology contribute to drug development? Disease modelling as a predictive tool

Posted on October 10, 2019 by Rose Ladwig

The paper “The Apoe-/- Mouse PhysioLab® Platform: A Validated Physiologically-based Mathematical Model of Atherosclerotic Plaque Progression in the Apoe-/- Mouse” by Jason Chan and colleagues [1] published in BioDiscovery 2012; 3: 2 is significant for several reasons. The …

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  • To see an interphase chromosome or: How a disease can be associated with specific nuclear genome organization
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