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Evolution of Conformational Disorder & Diversity of the P53 Interactome

Anne-Sophie Huart, Ted R. Hupp University of Edinburgh, Institute of Genetics and Molecular Medicine, p53 Signal Transduction Group, Crewe Road South, Edinburgh, EH4 2XR, Scotland,...

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Changes in the connective tissue element of the thyroid gland in normal and recurrent euthyroid goiter

Kalin Vidinov1, Nikolay Vidinov2, Manol Kalniev2, Dimo Krastev2 1USBALE “Acad. Iv. Penchev” Hospital, Department of Endocrine surgery, Medical University - Sofia, Bulgaria 2Department Anatomy, histology and...

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The alternate GNB3 splice variant, Gβ3s, exhibits an altered signalling response to EGF stimulation, which leads to enhanced cell migration

Hemanth Tummala1, Hilal S. Khalil1, Mohammad R. Islam2, Sarah J. Jones2, Ian R. Ellis2, Isabella D’Ascanio1, Nikolai Zhelev1*, Douglas H. Lester1* 1School of Science, Engineering...

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Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

Michael A. Idowu#, Hilal S. Khalil#, James L. Bown*, Nikolai Zhelev* School of Science, Engineering & Technology, University of Abertay Dundee, Bell Street, Dundee, UK,...

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Progesterone significantly enhances the mobility of boar spermatozoa

Johan M. Campbell, Anne L. Savage, Oladipo Madamidola, Kshitij Tamhane, Renalyn Soriano, Ashok K. Adya, Sean G. Brown* School of Science, Engineering & Technology, University...

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From Roscovitine to CYC202 to Seliciclib – from bench to bedside: discovery and development

Nikolai Zhelev1*, Dimitar Trifonov1, Shudong Wang2, Moustapha Hassan3,4, Ibrahim El Serafi3,Vanio Mitev5 1 School of Science, Engineering & Technology, University of Abertay Dundee, Bell Street, Dundee,UK,...

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DNA damage and mutation. Types of DNA damage

Stoyan Chakarov1*, Rumena Petkova2, George Ch Russev3, Nikolai Zhelev4 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology,...

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Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

Stoyan Chakarov1* , Rumena Petkova2 , George Ch Russev3 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology, Bulgarian Acad...

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