Treva Wells

The alternate GNB3 splice variant, Gβ3s, exhibits an altered signalling response to EGF stimulation, which leads to enhanced cell migration

Hemanth Tummala1, Hilal S. Khalil1, Mohammad R. Islam2, Sarah J. Jones2, Ian R. Ellis2, Isabella D’Ascanio1, Nikolai Zhelev1*, Douglas H. Lester1* 1School of Science, Engineering...

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

Michael A. Idowu#, Hilal S. Khalil#, James L. Bown*, Nikolai Zhelev* School of Science, Engineering & Technology, University of Abertay Dundee, Bell Street, Dundee, UK,...

Progesterone significantly enhances the mobility of boar spermatozoa

Johan M. Campbell, Anne L. Savage, Oladipo Madamidola, Kshitij Tamhane, Renalyn Soriano, Ashok K. Adya, Sean G. Brown* School of Science, Engineering & Technology, University...

From Roscovitine to CYC202 to Seliciclib – from bench to bedside: discovery and development

Nikolai Zhelev1*, Dimitar Trifonov1, Shudong Wang2, Moustapha Hassan3,4, Ibrahim El Serafi3,Vanio Mitev5 1 School of Science, Engineering & Technology, University of Abertay Dundee, Bell Street, Dundee,UK,...

DNA damage and mutation. Types of DNA damage

Stoyan Chakarov1*, Rumena Petkova2, George Ch Russev3, Nikolai Zhelev4 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology,...

Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

Stoyan Chakarov1* , Rumena Petkova2 , George Ch Russev3 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology, Bulgarian Acad...

DNA repair and carcinogenesis

Stoyan Chakarov1*, Rumena Petkova2, George Ch Russev3, Nikolai Zhelev4 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology,...

DNA damage and the circadian clock

Stoyan Chakarov1*, Rumena Petkova2, George Ch Russev3, Nikolai Zhelev4 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology,...

DNA repair systems

Stoyan Chakarov1* , Rumena Petkova2 , George Ch Russev3 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology, Bulgarian Acad...

Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds

Emilia Schax, Janek Neunaber, Frank Stahl, Johanna-Gabriela Walter, Thomas Scheper, Simone Eichner, Andreas Kirschning, Carsten Zeilinger 1Gottfried-Wilhelm Leibniz University Hannover, Institut für Technische Chemie und...

We heart cultured hearts. A comparative review of methodologies for targeted differentiation and maintenance of cardiomyocytes derived from pluripotent and multipotent stem cells

Arabadjiev A.1, Petkova R.2, Chakarov S.1, Pankov R.1, Zhelev N.3 1Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3CMCBR, Abertay University,...

NRF2 inhibition causes repression of ATM and ATR expression leading to aberrant DNA Damage Response

Hilal S. Khalil, Yusuf Deeni School of Science, Engineering and Technology, Abertay University, Dundee, DD1 1HG, United Kingdom Abstract Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a...
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