Treva Wells

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Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

Stoyan Chakarov1* , Rumena Petkova2 , George Ch Russev3 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology, Bulgarian Acad...

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DNA repair and carcinogenesis

Stoyan Chakarov1*, Rumena Petkova2, George Ch Russev3, Nikolai Zhelev4 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology,...

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DNA damage and the circadian clock

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DNA repair systems

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Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds

Emilia Schax, Janek Neunaber, Frank Stahl, Johanna-Gabriela Walter, Thomas Scheper, Simone Eichner, Andreas Kirschning, Carsten Zeilinger 1Gottfried-Wilhelm Leibniz University Hannover, Institut für Technische Chemie und...

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We heart cultured hearts. A comparative review of methodologies for targeted differentiation and maintenance of cardiomyocytes derived from pluripotent and multipotent stem cells

Arabadjiev A.1, Petkova R.2, Chakarov S.1, Pankov R.1, Zhelev N.3 1Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3CMCBR, Abertay University,...

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NRF2 inhibition causes repression of ATM and ATR expression leading to aberrant DNA Damage Response

Hilal S. Khalil, Yusuf Deeni School of Science, Engineering and Technology, Abertay University, Dundee, DD1 1HG, United Kingdom Abstract Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a...

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Small molecules and human cardiomyogenesis: Is there a bottleneck in current research?

Dimitar Trifonov BioDiscovery, Dundee Science Press, Dundee, Scotland Abstract Human pluripotent stem cell derived cardiomyocytes (hPSC-derived CMs) have a vast potential in drug discovery, disease modeling and...

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Human pluripotent stem-cell-derived cardiomyocytes in cardiovascular drug discovery and development

Kirsty Lewis, Kerry Falconer CMCBR, Abertay Uiversity, Dundee, Scotland, Bell Street, Dundee,UK, DD1 1HG Abstract Cardiovascular disease (CVD) is an alarming health problem responsible for a large...

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APOE4, oxidative stress and decreased repair capacity – a no-brainer. Faulty lipid metabolism and increased levels of oxidative damage may be risk factors in...

Ashima Nayyar1, Lubomira Chakalova2 1CMCBR, School of Science Engineering and Technology, Abertay University, Dundee DD1 1HG, UK 2Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad....

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Blood-Based Gene Expression in children with Autism spectrum disorder

Hristo Y. Ivanov1, Vili K. Stoyanova1,2, Nikolay T. Popov3, M. Bosheva1,2, Tihomir I. Vachev1,4 1Department of Pediatrics and Medical Genetics, Medical University, Plovdiv Vasil Aprilov...

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A de novo microdeletion 2p24.3-25.1 identified in a girl with global development delay

Hristo Y. Ivanov1#, Vili K. Stoyanova1,2#, Radoslava Vazharova3,4#, Aleksandar Linev2, Ivan Ivanov1,2, Samuil Ivanov4, Lubomir Balabanski4, Draga Toncheva4,5 1Medical University - Plovdiv, Department of Pediatrics...

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