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From Roscovitine to CYC202 to Seliciclib – from bench to bedside: discovery and development

Nikolai Zhelev1*, Dimitar Trifonov1, Shudong Wang2, Moustapha Hassan3,4, Ibrahim El Serafi3,Vanio Mitev5 1 School of Science, Engineering & Technology, University of Abertay Dundee, Bell Street, Dundee,UK,...

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DNA damage and mutation. Types of DNA damage

Stoyan Chakarov1*, Rumena Petkova2, George Ch Russev3, Nikolai Zhelev4 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology,...

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Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

Stoyan Chakarov1* , Rumena Petkova2 , George Ch Russev3 1 Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2 Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3 Institute of Molecular Biology, Bulgarian Acad...

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DNA repair and carcinogenesis

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DNA damage and the circadian clock

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DNA repair systems

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Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds

Emilia Schax, Janek Neunaber, Frank Stahl, Johanna-Gabriela Walter, Thomas Scheper, Simone Eichner, Andreas Kirschning, Carsten Zeilinger 1Gottfried-Wilhelm Leibniz University Hannover, Institut für Technische Chemie und...

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We heart cultured hearts. A comparative review of methodologies for targeted differentiation and maintenance of cardiomyocytes derived from pluripotent and multipotent stem cells

Arabadjiev A.1, Petkova R.2, Chakarov S.1, Pankov R.1, Zhelev N.3 1Sofia University "St. Kliment Ohridsky", Sofia, Bulgaria 2Scientific Technological Service (STS) Ltd., Sofia, Bulgaria 3CMCBR, Abertay University,...

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NRF2 inhibition causes repression of ATM and ATR expression leading to aberrant DNA Damage Response

Hilal S. Khalil, Yusuf Deeni School of Science, Engineering and Technology, Abertay University, Dundee, DD1 1HG, United Kingdom Abstract Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a...

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Small molecules and human cardiomyogenesis: Is there a bottleneck in current research?

Dimitar Trifonov BioDiscovery, Dundee Science Press, Dundee, Scotland Abstract Human pluripotent stem cell derived cardiomyocytes (hPSC-derived CMs) have a vast potential in drug discovery, disease modeling and...

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