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Modelling c-Abl Signalling in Activated Neutrophils: The Anti-inflammatory Effect of Seliciclib

Robert C. Jackson1, Tomas Radivoyevitch2 1Pharmacometrics Ltd., Cambridge, UK 2Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA Abstract When mammalian tissues are infected by...

Switching on p53: an essential role for protein phosphorylation?

Jayne Loughery, David Meek Division of Cancer Research, Medical Research Institute, Clinical Research Centre/Jacqui Wood Cancer Centre, The University of Dundee, James Arrott Drive, Ninewells...

Modulation of immune responses by the tumor suppressor p53

Julie Lowe, Maria Shatz, Michael A. Resnick, Daniel Menendez Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of...

Distinct target genes and effector processes appear to be critical for p53-activated responses to acute DNA damage versus p53-mediated tumour suppression

Liz J Valente1, 2, Andreas Strasser1, 2 1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia 2Department of Medical...

Small Molecule Inhibitors of MDM2-p53 and MDMX-p53 Interactions as New Cancer Therapeutics

Yujun Zhao, Denzil Bernard, Shaomeng Wang Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109,...

Evolution of Conformational Disorder & Diversity of the P53 Interactome

Anne-Sophie Huart, Ted R. Hupp University of Edinburgh, Institute of Genetics and Molecular Medicine, p53 Signal Transduction Group, Crewe Road South, Edinburgh, EH4 2XR, Scotland,...

Changes in the connective tissue element of the thyroid gland in normal and recurrent euthyroid goiter

Kalin Vidinov1, Nikolay Vidinov2, Manol Kalniev2, Dimo Krastev2 1USBALE “Acad. Iv. Penchev” Hospital, Department of Endocrine surgery, Medical University - Sofia, Bulgaria 2Department Anatomy, histology and...

The alternate GNB3 splice variant, Gβ3s, exhibits an altered signalling response to EGF stimulation, which leads to enhanced cell migration

Hemanth Tummala1, Hilal S. Khalil1, Mohammad R. Islam2, Sarah J. Jones2, Ian R. Ellis2, Isabella D’Ascanio1, Nikolai Zhelev1*, Douglas H. Lester1* 1School of Science, Engineering...

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

Michael A. Idowu#, Hilal S. Khalil#, James L. Bown*, Nikolai Zhelev* School of Science, Engineering & Technology, University of Abertay Dundee, Bell Street, Dundee, UK,...

Progesterone significantly enhances the mobility of boar spermatozoa

Johan M. Campbell, Anne L. Savage, Oladipo Madamidola, Kshitij Tamhane, Renalyn Soriano, Ashok K. Adya, Sean G. Brown* School of Science, Engineering & Technology, University...
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