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Does positioning of chromosomes 8 and 21 in interphase drive t(8;21) in acute myelogenous leukemia?

Moneeb A.K. Othman1, Amelie Lier1, Susann Junker1, Philipp Kempf1, Franziska Dorka1, Erich Gebhart2, Frenny J. Sheth3, Beata Grygalewicz4, Samarth Bhatt1, Anja Weise1, Kristin Mrasek1,...

Prevalence of oral lesions in HIV infected adult population of Mangalore, Karnataka, India

Mithra N. Hegde1*, Nidarsh D. Hegde2, Amit Malhotra1 1Department of Conservative Dentistry and Endodontics, A. B. Shetty Memorial Institute of Dental Sciences, NITTE University, Derelakatte,...

What can systems pharmacology contribute to drug development? Disease modelling as a predictive tool

Robert C. Jackson Pharmacometrics Ltd, Cambridge UK BioDiscovery2012; 4: 4; DOI: 10.7750/BioDiscovery.2012.4.4 Copyright: © 2012 Jackson. This is an open-access article distributed under the terms of the Creative...

To see an interphase chromosome or: How a disease can be associated with specific nuclear genome organization

Ivan Y. Iourov 1 Mental Health Research Center, Russian Academy of Medical Sciences, 119152 Moscow, Russia 2 Institute of Pediatrics and Children Surgery, Ministry of Health...

ATM in focus: A damage sensor and cancer target

Hilal S Khalil, Hemanth Tummala, Nikolai Zhelev School of Contemporary Sciences, University of Abertay Dundee, Dundee DD1 1HG, Scotland, UK Abstract The ability of a cell to...

Primed for the kill: occupying Bcl-2 to target death in acute myeloid leukaemia

Andrew Wei1,2*, Tse-Chieh Teh1 1The Australian Centre for Blood Diseases, Division of Blood Cancers, Monash University, Melbourne, Australia 2Department of Clinical Haematology, The Alfred Hospital, Commercial...

The aromatase inhibitor letrozole enhances the effect of doxorubicin and docetaxel in an MCF7 cell line model

Mary O’Neill1, Fiona E.M. Paulin1, Julie Vendrell1, Clinton W. Ali2, Alastair M. Thompson1,3* 1Dundee Cancer Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland,...

Bringing together all aspects of cancer research, prevention and treatment. A report from the 8th NCRI Cancer Conference

Dimitar Trifonov BioDiscovery, Dundee Science Press, Dundee, Scotland bstract The 8th NCRI Cancer Conference took place from 4th until 7th of November 2012 in the BT Convention Centre, Liverpool, UK....

Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients

Hemanth Tummala1, Alexey Goltsov1, Hilal S Khalil1, Anne Sproul2, Fiona Scott2, Vanio Mitev3, Nikolai Zhelev1 1School of Contemporary Sciences, Kydd Building, University of Abertay Dundee,...

Chromosome rearrangements in sublines of human embryonic stem cell lines hESM01 and hESM03

Tatyana V. Karamysheva1, Мaria А. Prokhorovich1,3, Maria A. Lagarkova2, Sergey L. Kiselev2, Thomas Liehr4, Nikolay B. Rubtsov1,3 1Institute of Cytology and Genetics, SB RAS, Novosibirsk,...
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